Gonzalo Guillén-Gosalbez

Imperial College London

Selected papers with our group

Guillén-Gosálbez-G, Sorribas, A. (2009) Identifying quantitative operation principles in metabolic pathways: a systematic method for searching feasible en zyme activity patterns leading to cellular adaptive responses. BMC Bioinformatics 2009, 10:386

Sorribas A, Pozo C, Vilaprinyo E, Guillén-Gosálbez G, Jimenez L, Alves R (2010) Optimization and evolution in metabolic pathways: global optimization techniques in Generalized Mass Action models. J.Biotechnol. 149: 141-153

Pozo C, Marin-Sanguino A, Guillén-Gosalbez G, Jimenez L, Alves R, Sorribas A. (2011) Steady-state global optimization of non-linear dynamic models through recasting into power-law canonical models. BMC Systems Biology 5:137

Pozo C, Guillén-Gosálbez G, Sorribas A, Jimenez L. (2012) Identifying the preferred subset of enzymatic profiles in nonlinear kinetic metabolic models via multi-objective global optimization and Pareto filters. PLoS ONE 7(9): e43487. doi:10.1371/journal.pone.0043487

Guillén-Gosálbez G, Miró A, Alves R, Sorribas A, Jimenez L. (2013) Identification of regulatory structure and kinetic parameters of biochemical networks via mixed-integer dynamic optimization. BMC Systems Biology 7(1):113

Eberhard O. Voit

Georgia Tech, USA

Papers in collaboration with our group

Curto, R., Voit, E.O., Sorribas, A., & Cascante, M. (1997). Validation and steady-state analysis of a power-law model of purine metabolism in man.  Biochem.J., 324, 761-775.

Curto R. Voit EO. Sorribas A. Cascante M. (1998 )Mathematical models of purine metabolism in man.Mathematical Biosciences 151(1):1-49.

Voit, E.O. & Sorribas, A.. Computer modeling of dinamically changin distributions of random variables.  Mathe.Comput.Modelling (2000) 31:217-225

Sorribas,A; March,J.; Voit,E.O Estimating age-related trends in cross-sectional studies using S-distributions Stat.Med. (2000) 19:697-713

Sorribas, A, Muiño, JM, Voit, EO. (2006) GS-distributions: a new family of distributions for continous unimodal variables. Computational Statistics and Data Analysis 50:2769-2798


Michael A. Savageau

UC Davis

Papers in collaboration with our group

Savageau, M.A. & Sorribas, A. (1989). Constraints among molecular and systemic properties: implications for physiological genetics.  J.Theor.Biol., 141, 93-115.

Sorribas, A. & Savageau, M.A. (1989). A comparison of variant theories of intact biochemical systems. I. Enzyme-enzyme interactions and biochemical systems theory.  Math.Biosci., 94, 161-193.

Sorribas, A. & Savageau, M.A. (1989). A comparison of variant theories of intact biochemical systems. II. Flux-oriented and metabolic control theories.  Math.Biosci., 94, 195-238.

Sorribas, A. & Savageau, M.A. (1989). Strategies for representing metabolic pathways within biochemical systems theory: reversible pathways.  Math.Biosci., 94, 239-269.

Alves R, Savageau MA. Comparing systemic properties of ensembles of biological networks by graphical and statistical methods. Bioinformatics. 2000 Jun;16(6):527-33.

Alves R, Savageau MA. Systemic properties of ensembles of metabolic networks: application of graphical and statistical methods to simple unbranched pathways. Bioinformatics. 2000 Jun;16(6):534-47.

Alves R, Savageau MA. Effect of overall feedback inhibition in unbranched biosynthetic pathways. Biophys J. 2000 Nov;79(5):2290-304.

Alves R, Savageau MA. Extending the method of mathematically controlled comparison to include numerical comparisons. Bioinformatics. 2000 Sep;16(9):786-98.

Alves R, Savageau MA. Irreversibility in unbranched pathways: preferred positions based on regulatory considerations. Biophys J. 2001 Mar;80(3):1174-85.

Alves R, Savageau MA. Comparative analysis of prototype two-component systems with either bifunctional or monofunctional sensors: differences in molecular structure and physiological function. Mol Microbiol. 2003 Apr;48(1):25-51.

Alves R, Savageau MA. Evidence of selection for low cognate amino acid bias in amino acid biosynthetic enzymes. Mol Microbiol. 2005 May;56(4):1017-34.

Igoshin OA, Alves R, Savageau MA. Hysteretic and graded responses in bacterial two-component signal transduction. Mol Microbiol. 2008 Jun;68(5):1196-215. doi: 10.1111/j.1365-2958.2008.06221.x. Epub 2008 Mar 19.

Moura A, Savageau MA, Alves R. Relative amino acid composition signatures of organisms and environments. PLoS One. 2013 Oct 25;8(10):e77319. doi: 10.1371/journal.pone.0077319. eCollection 2013.


Paul Chirstou

ICREA Professor, Agrotecnio - University of Lleida

Papers in collaboration with our group

Farré G, Maiam Rivera S, Alves R, Vilaprinyo E, Sorribas A, Canela R, Naqvi S, Sandmann G, Capell T, Zhu C, Christou P (2013) Targeted transcriptomic and metabolic profiling reveals temporal bottlenecks in the maize carotenoid pathway that may be addressed by multigene engineeringThe Plant Journal doi: 10.1111/tpj.12214

Bai, C; Maiam R, Sol; Medina, V; Alves, R; Vilaprinyo, E; Sorribas, A; Canela, R; Capell, T; Sandmann, G; Christou, P; Zhu, C. (2014) An in vitro system for the rapid functional characterization of genes involved in carotenoid biosynthesis and accumulation. The Plant Journal (2014) doi: 10.1111/tpj.12384

Comas J, Benfeitas R, Vilaprinyo E, Sorribas A, Solsona F, Farré G, Berman J, Zorrilla U, Capell T, Sandmann G, Zhu C, Christou P, Alves R. (2016) Identification of line-specific strategies for improving carotenoid production in synthetic maize through data-driven mathematical modeling. Plant J. 2016 Sep;87(5):455-71. doi: 10.1111/tpj.13210. Epub 2016 Jul 18.